Acetyl Hexapeptide-8 (Argireline)

Overview:

Acetyl Hexapeptide-8, commonly known as Argireline, is a synthetic peptide derived from a fragment of SNAP-25, a substrate of botulinum toxin (Botox). It is widely used in anti-aging skincare products for its potential to reduce the appearance of fine lines and wrinkles. ​
 

Chemical Structure and Properties:

This hexapeptide consists of six amino acids: Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂. Its structure allows it to interfere with neurotransmitter release, leading to muscle relaxation. ​
 

Source and Extraction:

Acetyl Hexapeptide-8 is synthetically produced through solid-phase peptide synthesis, ensuring high purity and consistency.​

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Cosmetic Functions:

Anti-Wrinkle Agent, Inhibits facial muscle contractions, reducing the depth of wrinkles.​

Benefits for the Skin:

Wrinkle Reduction: Regular application can lead to a noticeable decrease in wrinkle depth, particularly on the forehead and around the eyes.​
Non-Invasive Alternative: Offers a needle-free option for those seeking Botox-like effects.​

Safety and Regulatory Status:

Studies have shown that Acetyl Hexapeptide-8 is generally safe for topical use, with no significant adverse effects reported. ​